rs10732516 polymorphism at the IGF2/H19 locus associates with genotype-specific effects on placental DNA methylation and birth weight of newborns conceived by assisted reproductive technology.

Heidi MarjonenPauliina AuvinenHanna KahilaOlga TšuikoSulev KõksAiri TiiratsTriin ViltropTimo TuuriViveca Söderström-AnttilaAnne-Maria SuikkariAndres SalumetsAila TiitinenNina Kaminen-Ahola

Published in: Clinical epigenetics (2018)

The observed DNA methylation changes together with the phenotypic findings suggest that rs10732516 polymorphism associates with the effects of ART in a parent-of-origin manner. Therefore, this polymorphism should be considered when the effects of environmental factors on embryonic development are studied.

Keyphrases

dna methylation
birth weight
gestational age
weight gain
genome wide
gene expression
preterm birth
pregnant women
hiv infected
low birth weight
copy number
body mass index
antiretroviral therapy
preterm infants
cell proliferation
physical activity
growth hormone
weight loss