Stability-indicating RP-HPLC method development and validation for Eltrombopag olamine in the presence of impurities and degradation products. Robustness by Design of expert.

Rajeshwari Dandabattina B Subramanian Velusamy Karuna Sree Merugu Sharath Babu Haridasyam Naresh Kumar Katari Leela Prasad Kowtharapu

Published in: Journal of AOAC International (2022)

The proposed article is the first-ever RP HPLC method for determining impurities in ELO film-coated tablets and drug substances. QbD concept was utilized to verify the method performance.

Keyphrases

ms ms
simultaneous determination
high performance liquid chromatography
emergency department
drinking water
room temperature
drug induced
reduced graphene oxide