Risk of malignancy and clinical outcomes of cyst fluid only nodules in the thyroid based on ultrasound and aspiration cytology.

We propose that CFO nodules should be classified as separate from ND/UNS nodules; they should be categorized as a subtype of benign nodules. However, it is essential that fine-needle aspiration cytology be performed under ultrasound-guided real-time visualization of needle placement in the target nodule in all cases.