Sulphated penta-galloyl glucopyranoside (SPGG) is glycosaminoglycan mimetic allosteric inhibitor of cathepsin G.
Rami A Al-HoraniDaniel K AfosahSrabani KarKholoud F AliterMadhusoodanan MottamalPublished in: RPS pharmacy and pharmacology reports (2023)
We present the discovery of SPGG as the first small molecule, potent, allosteric glycosaminoglycan mimetic inhibitor of CatG. SPGG is expected to open a major route to clinically relevant allosteric CatG anti-inflammatory agents.