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Alternaphenol B2, a new IDH1 inhibitor from the coral-derived fungus Parengyodontium album SCSIO SX7W11.

Xiaoyue LiWenbin ShenGuochao LiYongxiang SongXinhua LuNai-Kei WongYan Yan
Published in: Natural product research (2023)
A new aromatic polyketide, alternaphenol B2 ( 1 ), and four known compounds ( 2-5 ) were isolated from the coral - derived fungus Parengyodontium album SCSIO SX7W11. Their structures were elucidated by high-resolution mass spectrometry, 1D and 2D NMR spectroscopy and comparison with reported literatures. Compounds 1 and 2 exhibited selective inhibitory activity against isocitrate dehydrogenase mutant R132H (IDH1m), with IC 50 values of 41.9 and 27.7 μM, respectively. Our findings thus provide a fresh incentive for investigation on IDH1m inhibitors as lead compounds for cancer treatment.
Keyphrases
  • wild type
  • high resolution mass spectrometry
  • low grade
  • liquid chromatography
  • mass spectrometry
  • gas chromatography
  • ultra high performance liquid chromatography
  • high grade
  • ms ms