Clusters of cognitive performance predict long-term cognitive impairment in elderly patients with subjective memory complaints and healthy controls.
Adolfo Jiménez-HueteRafael Villino-RodríguezMirla M Ríos-RiveraTeresa RognoniGenoveva Montoya-MurilloCarlota ArrondoCarolina ZapataMaría Cruz Rodríguez-OrozMario Riverolnull nullPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Patients with subjective memory complaints include two cognitive clusters. Assignment to the lower performance cluster increases risk of cognitive impairment. This cluster shows a pattern of biomarkers consistent with incipient Alzheimer's disease pathology. The same cognitive cluster structure is found in healthy controls. The effect of memory complaints on risk of cognitive decline is small and confounded.