Electroacupuncture Relieves Visceral Hypersensitivity by Inactivating Protease-Activated Receptor 2 in a Rat Model of Postinfectious Irritable Bowel Syndrome.

Wanli XuMengqian YuanXiaoliang WuHao GengLu ChenJunling ZhouYafang SongLi-Xia Pei Jian-Hua Sun

Published in: Evidence-based complementary and alternative medicine : eCAM (2018)

These results suggest that EA alleviates VH symptoms through downregulation of the levels of the TPSP/PAR2/SP/CGRP signaling axis in colon tissues in PI-IBS rats. Together, our data suggests that PAR2 plays a critical role in the analgesic effect of EA on VH in PI-IBS.

Keyphrases

irritable bowel syndrome
neuropathic pain
electronic health record
gene expression
cell proliferation
signaling pathway
insulin resistance
big data
drug induced
anti inflammatory
spinal cord
mouse model
type diabetes
cerebral ischemia
skeletal muscle
subarachnoid hemorrhage