The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation.
Esther Cw de BoerAstrid Jf ThielenJeroen D LangereisAngela KampMieke C BrouwerNienke OskamMarlieke L M JongsmaApril J BaralRobbert M SpaapenSacha S ZeerlederGestur VidarssonTheo RispensDiana WoutersRichard B PouwIlse JongeriusPublished in: Clinical & translational immunology (2023)
The AP can be bypassed through efficient CP activation. The AP amplification loop has a role in complement activation during conditions of modest activation via the CP, when it can allow for efficient complement-mediated killing.