Insulin sensitivity and insulin secretion in adults with Friedreich's Ataxia: the role of skeletal muscle.
Jaclyn G TamaroffSara NguyenNeil E WilsonDarko StefanovskiRui XiaoTheresa ScattergoodChristopher CapiolaGayatri Maria SchurJulia DunnAnna DedioKristin WadeHardik ShahRohit SharmaVamsi K MoothaAndrea KellyKimberly Y LinDavid R LynchRavinder ReddyMichael R RickelsShana E McCormackPublished in: The Journal of clinical endocrinology and metabolism (2024)
Lower mitochondrial OXPHOS capacity, inactivity, and visceral adiposity contribute to lower insulin sensitivity in FRDA. Higher insulin secretion appears compensatory, and when inadequate, could herald DM. Further studies are needed to determine if muscle- or adipose-focused interventions could delay FRDA-related DM.