Identification of a Suitable Untargeted Agent for the Clinical Translation of ABY-029 Paired-Agent Imaging in Fluorescence-Guided Surgery.
Cheng WangXiaochun XuSassan HodgeEunice Y ChenP Jack HoopesKenneth M TichauerKimberley S SamkoePublished in: Molecular imaging and biology (2021)
PAI is a highly promising methodology for increasing detection of tumors in fluorescence-guided surgery. Although not yet clinically approved, IRDye 680LT demonstrates promise as an untargeted agent when paired with ABY-029. The clinical translation of PAI to maximize tumor excision, while minimizing normal tissue removal, could improve both patient survival and life quality.
Keyphrases
- minimally invasive
- coronary artery bypass
- mass spectrometry
- single molecule
- high resolution
- surgical site infection
- liquid chromatography
- gas chromatography mass spectrometry
- energy transfer
- coronary artery disease
- photodynamic therapy
- percutaneous coronary intervention
- loop mediated isothermal amplification
- quality improvement