Walk More, Eat Less, Don't Stress.
Omer KucukPublished in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2022)
Unhealthy diet, obesity, lack of physical activity, and psychologic stress are associated with increased inflammation, oxidative stress, insulin resistance, and DNA methylation, which are the main mechanisms of chronic diseases such as cancer, hypertension, diabetes, cardiovascular disease, and Alzheimer's disease. It has recently been found that healthy diet and physical activity can reduce inflammatory markers and improve insulin sensitivity resulting in better survivorship outcomes in patients with prostate cancer. An "anti-inflammatory" lifestyle, including physical activity, healthy body weight, healthy diet, and stress reduction, has been associated with decreased cancer risk and progression. Epigenetic changes due to DNA methylation and altered gene expression associated with unhealthy lifestyle can be modulated by healthy behaviors. National Center for Complementary and Integrative Health (NCCIH) focuses on healthy lifestyle, and it supports research on psychologic and physical approaches including dietary supplements and plant-based products, as well as mind and body approaches, such as yoga, massage, meditation, mindfulness-based stress reduction, and acupuncture. See related article by Langlais et al., p. 1760.
Keyphrases
- physical activity
- dna methylation
- gene expression
- cardiovascular disease
- weight loss
- insulin resistance
- oxidative stress
- prostate cancer
- metabolic syndrome
- type diabetes
- body weight
- body mass index
- genome wide
- anti inflammatory
- healthcare
- public health
- mental health
- blood pressure
- stress induced
- sleep quality
- squamous cell carcinoma
- radical prostatectomy
- chronic pain
- heat stress
- papillary thyroid
- quality improvement
- dna damage
- risk assessment
- social media
- signaling pathway
- network analysis
- heat shock
- climate change
- heat shock protein