Deficiency of the pattern-recognition receptor CD14 protects against joint pathology and functional decline in a murine model of osteoarthritis.

Nisha SambamurthyCheng ZhouVu NguyenRyan SmalleyKurt D HankensonGeorge R DodgeCarla R Scanzello

Published in: PloS one (2018)

CD14 plays an important role in progression of structural and functional features of OA in the DMM model, and may provide a new target for therapeutic development.

Keyphrases

knee osteoarthritis
rheumatoid arthritis