Biodegradable Nanoparticles Enhanced Adhesiveness of Mussel-Like Hydrogels at Tissue Interface.
Nikhil PandeyAmirhossein HakamivalaCancan XuPrashant HariharanBoris RadionovZhong HuangJun LiaoLiping TangPhilippe ZimmernKytai T NguyenYi HongPublished in: Advanced healthcare materials (2017)
Popular bioadhesives, such as fibrin, cyanoacrylate, and albumin-glutaraldehyde based materials, have been applied for clinical applications in wound healing, drug delivery, and bone and soft tissue engineering; however, their performances are limited by weak adhesion strength and rapid degradation. In this study a mussel-inspired, nanocomposite-based, biodegradable tissue adhesive is developed by blending poly(lactic-co-glycolic acid) (PLGA) or N-hydroxysuccinimide modified PLGA nanoparticles (PLGA-NHS) with mussel-inspired alginate-dopamine polymer (Alg-Dopa). Adhesive strength measurement of the nanocomposites on porcine skin-muscle constructs reveals that the incorporation of nanoparticles in Alg-Dopa significantly enhances the tissue adhesive strength compared to the mussel-inspired adhesive alone. The nanocomposite formed by PLGA-NHS nanoparticles shows higher lap shear strength of 33 ± 3 kPa, compared to that of Alg-Dopa hydrogel alone (14 ± 2 kPa). In addition, these nanocomposites are degradable and cytocompatible in vitro, and elicit in vivo minimal inflammatory responses in a rat model, suggesting clinical potential of these nanocomposites as bioadhesives.
Keyphrases
- drug delivery
- reduced graphene oxide
- tissue engineering
- wound healing
- drug release
- cancer therapy
- carbon nanotubes
- visible light
- patient safety
- walled carbon nanotubes
- gold nanoparticles
- quantum dots
- soft tissue
- bone mineral density
- escherichia coli
- climate change
- postmenopausal women
- metabolic syndrome
- mass spectrometry
- human health
- pseudomonas aeruginosa
- cystic fibrosis
- highly efficient
- cell migration
- sensitive detection
- cell adhesion