The amazing cN-II, the enzyme that keeps us busy.

Published in: Nucleosides, nucleotides & nucleic acids (2021)

cN-II is a cytosolic 5'-nucleotidase with preference for IMP and GMP over AMP. The enzyme has been extensively studied over the last 20-30 years both for its enzymatic activity, structure, role in nucleotide metabolism and in cell biology, as well as in diseases. With the aim of highlighting the complexity of the enzyme, I will, as during PP21, present work from our group and others working on cN-II and its various roles and not give an exhaustive overview of new data.

Keyphrases

lymph node metastasis
single cell
electronic health record
hydrogen peroxide
big data
protein kinase
cell therapy
pseudomonas aeruginosa
bone marrow
mesenchymal stem cells
nitric oxide
deep learning
data analysis