Total synthesis of highly oxygenated phomopsol B via acid-induced etherification to construct a bridged structure.

The first total synthesis of phomopsol B has been achieved in a racemic form. The synthesis comprises a deacetylative cyclization to construct a bicyclic skeleton followed by primary alcohol-assisted dihydroxylation, ether cyclization to construct a dioxabicyclo [3.2.1] skeleton and γ-lactone formation based on oxidation by TEMPO.