Free water imaging of the cholinergic system in dementia with Lewy bodies and Alzheimer's disease.

Julia SchumacherNicola J RayCalum A HamiltonMaurizio BergaminoPaul C DonaghyMichael FirbankRosie WatsonGemma RobertsLouise AllanNicola BarnettJohn T O'BrienAlan J ThomasJohn-Paul Taylor

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)

Free water in the NBM-cortical cholinergic pathways is increased in AD and DLB. NBM-cortical pathway integrity is related to overall cognitive performance. Free water in the PPN-thalamus cholinergic pathway is only increased in DLB, not AD. PPN-thalamus pathway integrity might be related to visual hallucinations in DLB.

Keyphrases

deep brain stimulation
high resolution
mild cognitive impairment
parkinson disease
cognitive decline
mass spectrometry
fluorescence imaging