Serum complement proteomics reveal biomarkers for hypertension disorder of pregnancy and the potential role of Clusterin.

Shanshui ZengMengru HanMin JiangFei LiuYanwei HuYan LongChunyan ZhuFangling ZengQiangsheng GanWeitao YeWenjin FuHongling Yang

Published in: Reproductive biology and endocrinology : RB&E (2021)

Complement proteins may play an essential role in the occurrence of HDP by acting on trophoblast cells. CLU may be a high-risk factor for HDP, and the models combining candidates show reasonable screening efficiency of HDP in the first half of pregnancy.

Keyphrases

preterm birth
induced apoptosis
pregnancy outcomes
blood pressure
cell cycle arrest
risk assessment
mass spectrometry
genome wide
pregnant women
oxidative stress
signaling pathway
dna methylation