RBP4 promotes denervation-induced muscle atrophy through STRA6-dependent pathway.

Kang-Zhen ZhangJia-Wen LiJin-Shui XuZheng-Kai ShenYu-Shuang LinCan ZhaoXiang LuYun-Feng RuiWei Gao

Published in: Journal of cachexia, sarcopenia and muscle (2024)

In conclusion, our data reveal that RBP4 promotes fat infiltration and muscle atrophy through a STRA6-dependent and JAK2/STAT3 pathway-mediated mechanism in denervated skeletal muscle. Our results suggest that lowering RBP4 levels might serve as a promising therapeutic approach for prevention and treatment of muscle atrophy.

Keyphrases

skeletal muscle
insulin resistance
adipose tissue
high glucose
electronic health record
genome wide
diabetic rats
metabolic syndrome
oxidative stress
endothelial cells
deep learning
artificial intelligence