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Ultrasound-Assisted Extraction of Total Saponins from Aralia taibaiensis : Process Optimization, Phytochemical Characterization, and Mechanism of α-Glucosidase Inhibition.

Huan LiBingtao ZhaiJing SunYu FanJunbo ZouJiangxue ChengXiaofei ZhangYajun ShiDongyan Guo
Published in: Drug design, development and therapy (2022)
The optimal extraction conditions identified here established a basis for future scale-up of ultrasound extraction parameters with the potential for obtaining maximum yields. In vitro enzyme inhibition experiments investigated the mechanism of the TSAT interaction with α-glucosidase and further explored whether araloside A may be the main contributor to the good inhibition of α-glucosidase activity by TSAT.
Keyphrases
  • molecular docking
  • magnetic resonance imaging
  • molecular dynamics simulations
  • single molecule
  • high speed