Impact of Surgery-Induced Myeloid-derived Suppressor Cells and the NOX2/ROS Axis on Postoperative Survival in Human Pancreatic Cancer.

Hanna Grauers Wiktorin Ebru Aydin Roberta Kiffin Caroline Vilhav Johan Bourghardt Fagman Mustafa Kaya Sanchari Paul Beatrice Westman Svein Olav Bratlie Peter Naredi Kristoffer Hellstrand Anna Martner

Published in: Cancer research communications (2024)

Pancreatic cancer surgery triggered pronounced accumulation of NOX2+ myeloid-derived suppressor cells that inhibited NK cell function and negatively prognosticated postoperative patient survival. We propose the targeting of M-MDSC as a conceivable strategy to reduce postoperative immunosuppression in pancreatic cancer.

Keyphrases

induced apoptosis
patients undergoing
minimally invasive
cell cycle arrest
coronary artery bypass
reactive oxygen species
endothelial cells
cell death
case report
surgical site infection
cancer therapy
drug induced
coronary artery disease
induced pluripotent stem cells
pi k akt