Molecular and Spatial Signatures of Mouse Embryonic Endothelial Cells at Single-Cell Resolution.

Jian ChenXiaoran Zhang Daniel M DeLaughterMichael A TrembleyShaila Saifee Feng Xiao Jiehui Chen Pingzhu Zhou Christine E Seidman Jonathan G Seidman William T Pu

Published in: Circulation research (2024)

Our results provide a spatiotemporal map of embryonic EC heterogeneity at single-cell resolution and demonstrate that the diversity of ECs in the embryo arises from both tissue origin and vascular-bed position. Developing aECs and vECs share common venous-featured capillary precursors and are regulated by distinct transcriptional regulatory networks.

Keyphrases

single cell
rna seq
endothelial cells
single molecule
transcription factor
high throughput
gene expression
high glucose
dna methylation
vascular endothelial growth factor
heat shock protein