Montelukast improves disease outcome in SOD1 G93A female mice by counteracting oligodendrocyte dysfunction and aberrant glial reactivity.

Stefano RaffaeleNhung NguyenMarco MilaneseFrancesca C MannellaMarta BoccazziGiulia FrumentoGiambattista BonannoMaria P AbbracchioTiziana BonifacinoMarta Fumagalli

Published in: British journal of pharmacology (2024)

Our results provide the first preclinical evidence indicating that repurposing of MTK, a safe and marketed anti-asthmatic drug, may be a promising sex-specific strategy for personalized ALS treatment.

Keyphrases

amyotrophic lateral sclerosis
oxidative stress
neuropathic pain
high fat diet induced
combination therapy
spinal cord
mesenchymal stem cells
chronic obstructive pulmonary disease
skeletal muscle
insulin resistance
air pollution
electronic health record