High salt intake activates the hypothalamic-pituitary-adrenal axis, amplifies the stress response, and alters tissue glucocorticoid exposure in mice.

Michelle L GumzGeorgios KrilisCeline GrenierDavid SeversAlicja CzopekJessica R IvyMark NixonMegan C HolmesDawn E W Livingstone Ewout J Hoorn Neeraj Dhaun Matthew A Bailey

Published in: Cardiovascular research (2022)

Chronic high salt intake amplifies basal and stress-induced glucocorticoid levels and resets glucocorticoid biology centrally, peripherally and within cells.

Keyphrases

stress induced
induced apoptosis
cell cycle arrest
weight gain
type diabetes
metabolic syndrome
oxidative stress
cell death
endoplasmic reticulum stress
cell proliferation
body mass index
pi k akt