Non-invasive three-dimensional power Doppler imaging for the assessment of acute cerebral blood flow alteration in a mouse model of subarachnoid haemorrhage.
Shuzo YamamotoTatsushi MutohKazumasu SasakiTomoko MutohYasuko TatewakiYasuyuki TakiPublished in: Clinical and experimental pharmacology & physiology (2020)
We aimed to evaluate the feasibility of a non-invasive method of cerebral blood flow (CBF) measurement using high-frequency power Doppler ultrasound imaging in a mouse model of subarachnoid haemorrhage (SAH). The 3-dimensionally (3D) reconstructed blood flow signals (%vascularity) within the brain volume of the middle cerebral artery territory correlated well with reference parameters, baseline carotid artery blood flow (r2 = 0.52, P < 0.0001) and normalized CBF changes (r2 = 0.74 P < 0.0001). These data suggest that the 3D power Doppler analysis may have the potential for reflecting real-time CBF changes during the acute phase of experimental SAH, which may be applicable to preclinical studies on early brain injury.
Keyphrases
- blood flow
- cerebral blood flow
- brain injury
- high frequency
- mouse model
- middle cerebral artery
- transcranial magnetic stimulation
- subarachnoid hemorrhage
- cerebral ischemia
- internal carotid artery
- high resolution
- liver failure
- white matter
- respiratory failure
- resting state
- electronic health record
- cell therapy
- multiple sclerosis
- stem cells
- big data
- risk assessment
- climate change
- machine learning
- bone marrow
- functional connectivity
- acute respiratory distress syndrome
- photodynamic therapy
- data analysis
- extracorporeal membrane oxygenation