Production, purification, and radiolabeling of the 203Pb/212Pb theranostic pair.
Brooke L McNeilAndrew K H RobertsonWinnie FuHua YangCornelia HoehrCaterina F RamogidaPaul SchafferPublished in: EJNMMI radiopharmacy and chemistry (2021)
The production of 203Pb and 212Pb was established using TRIUMF 13 MeV and 500 MeV cyclotrons, respectively. Both production methods provided radiometals suitable for subsequent radiolabeling reactions using known and novel chelates. Furthermore, the novel chelate DOTA-3Py may be a good candidate for biomolecule conjugation and further theranostic 212Pb/203Pb studies.