Treatment with soluble CD24 attenuates COVID-19-associated systemic immunopathology.

No-Joon SongCarter AllenAnna E VilgelmBrian P RiesenbergKevin P WellerKelsi ReynoldsKarthik B ChakravarthyAmrendra KumarAastha KhatiwadaZequn SunAnjun MaYuzhou ChangMohamed YusufAnqi LiCong ZengJohn P EvansDonna BucciManuja GunasenaMenglin XuNamal P M LiyanageChelsea BolyardMaria VelegrakiShan-Lu LiuQin MaMartin DevenportYang LiuPan ZhengCarlos D MalvestuttoDongjun ChungZihai Li

Published in: Journal of hematology & oncology (2022)

Our data demonstrate that CD24Fc rapidly down-modulates systemic inflammation and restores immune homeostasis in SARS-CoV-2-infected individuals, supporting further development of CD24Fc as a novel therapeutic against severe COVID-19.

Keyphrases

sars cov
coronavirus disease
respiratory syndrome coronavirus
nk cells
early onset
electronic health record
big data
artificial intelligence