A novel substitution of proline (P32L) destabilises β2-microglobulin inducing hereditary systemic amyloidosis.
Tatiana ProkaevaTracy JoshiElena S KlimtchukVictoria M GibsonBrian SpencerOmar SiddiqiDobrin NedelkovYueming HuJohn L BerkSarah A M CuddySurendra DasariApril ChiuLauren A ChoateEllen Darcy McPhailHaili CuiHui ChenEric J BurksVaishali SanchorawalaLawreen H ConnorsPublished in: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis (2022)
This work provides both clinical and experimental evidence supporting the critical role of P32 residue replacement in β2M amyloid fibrillogenesis.
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