Treatment potential of LPCN 1144 on liver health and metabolic regulation in a non-genomic, high fat diet induced NASH rabbit model.

P ComeglioE SarchielliS FilippiI CellaiG GuarnieriA MorelliG RastrelliE MaseroliS CiprianiT MelloA GalliB J BrunoK KimK VangaraK PapangkornN ChidambaramM V PatelM MaggiLinda Vignozzi

Published in: Journal of endocrinological investigation (2021)

Histological and biomarker analyses demonstrate that LPCN 1144 improved HFD-induced hepatic fibrosis and NASH biochemical, biomolecular and histochemical features. These preclinical findings support a therapeutic potential of LPCN 1144 in the treatment of NASH and of hepatic fibrosis.

Keyphrases

high fat diet induced
healthcare
public health
insulin resistance
high fat diet
stem cells
type diabetes
risk assessment
oxidative stress
metabolic syndrome
adipose tissue
cell therapy
human health
skeletal muscle
drug induced