Mimicking the breast metastatic microenvironment: characterization of a novel syngeneic model of HER2 + breast cancer.
Aaron G BaughEdgar GonzalezValerie H NarumiJesse KregerYingtong LiuChristine RafieSofi CastanonJulie JangLuciane T KagoharaDimitra P AnastasiadouJames LeathermanTodd D ArmstrongIsaac ChanGeorge S KaragiannisElizabeth M JaffeeAdam L MacLeanEvanthia T Roussos TorresPublished in: bioRxiv : the preprint server for biology (2024)
We characterize a new syngeneic, immune-competent murine model of breast cancer (NT2.5-LM) that yields rapid and widespread metastases, preserves spontaneous metastasis, and provides a model for studying novel therapeutic interventions.