Evidence for the placenta-brain axis: multi-omic kernel aggregation predicts intellectual and social impairment in children born extremely preterm.

Hudson P Santos Arjun Bhattacharya Robert M Joseph Lisa Smeester Karl C K Kuban Carmen J Marsit Thomas Michael O'Shea Rebecca C Fry

Published in: Molecular autism (2020)

Aggregating information from biomarkers within and among molecular data types improves prediction of complex traits like social and intellectual ability in children born extremely preterm, suggesting that traits within the placenta-brain axis may be omnigenic.

Keyphrases

low birth weight
gestational age
preterm birth
young adults
preterm infants
healthcare
white matter
resting state
mental health
genome wide
functional connectivity
electronic health record
machine learning
gene expression
social media
subarachnoid hemorrhage