Coenzyme Q10 Regulates Antioxidative Stress and Autophagy in Acute Myocardial Ischemia-Reperfusion Injury.

Published in: Oxidative medicine and cellular longevity (2017)

This study reveals that CQ10 preconditioning regulates antioxidant levels and the oxidant balance, enhances autophagy, reduces myocardial apoptosis and death, and improves cardiac function in rats with acute ischemia-reperfusion injury. These results imply that CQ10 protects against acute myocardial ischemia-reperfusion injury via the antioxidative stress and autophagy pathways.

Keyphrases

pi k akt
ischemia reperfusion injury
signaling pathway
oxidative stress
cell cycle arrest
liver failure
cell proliferation
endoplasmic reticulum stress
respiratory failure
cell death
anti inflammatory
left ventricular
aortic dissection
drug induced
hepatitis b virus
heart failure
stress induced
blood brain barrier