Ragulator-a multifaceted regulator of lysosomal signaling and trafficking.

Published in: The Journal of cell biology (2017)

The lysosomal Ragulator complex regulates cell metabolism and growth by coordinating the activities of metabolic signaling pathways with nutrient availability. In this issue, Filipek et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201703061) and Pu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201703094) introduce a role for Ragulator in growth factor- and nutrient-regulated lysosomal trafficking.

Keyphrases

growth factor
single cell
cell therapy
signaling pathway
transcription factor
oxidative stress
cell proliferation
bone marrow
mesenchymal stem cells
endoplasmic reticulum stress
induced apoptosis