The isoprenoid end product N6-isopentenyladenosine reduces inflammatory response through the inhibition of the NFκB and STAT3 pathways in cystic fibrosis cells.
Antonietta SantoroElena CiagliaVanessa NicolinAlessandra PescatoreLucia ProtaMario CapunzoMatilde V UrsiniStefania L NoriMaurizio BifulcoPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2017)
Our findings indicate that iPA can exert anti-inflammatory activity especially in the cases of excessive inflammatory response as in CF.