Early enterovirus translation deficits extend viral RNA replication and elicit sustained MDA5-directed innate signaling.

Mikhail I DobrikovElena Y DobrikovaDasean T Nardone-WhiteZachary P McKayMichael C BrownMatthias Gromeier

Published in: mBio (2023)

. Here we unraveled EV-host relations that control suppression of host type-I IFN responses and show that PVSRIPO's deficient immediate host eIF4G cleavage generates unopposed MDA5-directed downstream signaling cascades resulting in sustained type-I IFN release.

Keyphrases

immune response
breast cancer cells
dendritic cells
traumatic brain injury
sars cov
dna binding
transcription factor
cell death
signaling pathway