Combined Treatment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Endothelial Cells Regenerate the Infarcted Heart in Mice and Non-Human Primates.

Yu-Che ChengMarvin L HsiehChen-Ju LinCindy M C ChangChing-Ying HuangRiley PuntneyAmy Wu MoyChien-Yu TingDarien Zhing Herr ChanMartin W NicholsonPo-Ju LinHung-Chih ChenGina C KimJianhua ZhangJennifer CoonenPuja Basu Heather A SimmonsYen-Wen LiuTimothy A HackerTimothy J Kamp Patrick Ching-Ho Hsieh

Published in: Circulation (2023)

These results demonstrate the synergistic effect of combining iPSC-derived ECs and CMs for therapy in the postmyocardial infarction heart, enabling a promising strategy toward clinical translation.

Keyphrases

endothelial cells
high glucose
induced pluripotent stem cells
heart failure
atrial fibrillation
vascular endothelial growth factor
stem cells
oxidative stress
diabetic rats
type diabetes
drug delivery
mesenchymal stem cells
bone marrow
cell therapy
combination therapy