Cotton wool-like ion-doped bioactive glass nanofibers: Investigation of Zn and Cu combined effect.

Electrospinning is a versatile and straightforward technique to produce nanofibrous mats with different morphologies. In addition, by optimizing the solution, processing, and environmental parameters, three-dimensional (3D) nanofibrous scaffolds can also be created using this method. In this work, the preparation and characterization of bioactive glass scaffolds based on the SiO2-CaO sol-gel system, abiomaterial with a highly reactive surface, was reported. The electrospinning technique was combined with sol-gel methods to obtain nanofibrous 3D cotton wool-like scaffolds. The addition of zinc and copper ions to the calcium silica system was examined, and the influence of these ions on the material properties and characteristics was investigated by various characterization techniques, from morphological and chemical to antibacterial, wound closure assay, cell viability and ion release. Our findings suggested that the cotton wool-like ion-doped bioactive glass nanofibers are promising for wound healing applications.&#xD.