Quantitative validation of a visual rating scale for frontal atrophy: associations with clinical status, APOE e4, CSF biomarkers and cognition.

Daniel FerreiraLena CavallinTobias GranbergOlof LindbergCarlos AguilarPatrizia MecocciBruno VellasMagda TsolakiIwona KłoszewskaHilkka SoininenSimon LovestoneAndrew SimmonsLars-Olof WahlundEric Westmannull null

Published in: European radiology (2015)

• The GCA-F visual rating scale reliably reflects frontal brain atrophy. • Orbitofrontal, dorsolateral, and motor cortices are the most contributing regions. • GCA-F shows significant associations with clinical status and cognition. • GCA-F may be supportive diagnostic tool for disorders demonstrating predominant frontal atrophy. • GCA-F may be feasible for use in radiological routine.

Keyphrases

working memory
functional connectivity
white matter
resting state
mild cognitive impairment
cognitive decline
type diabetes
transcranial magnetic stimulation
clinical practice
adipose tissue
transcranial direct current stimulation
prefrontal cortex
high frequency
blood brain barrier