Applying the ILAE diagnostic criteria for Lennox-Gastaut syndrome in the real-world setting: A multicenter retrospective cohort study.
Russell NightscalesZhibin Chen MBiostatSarah N BarnardClarissa AuvrezGerard TaoShobi SivathambooCaitlin BennettMaria RychkovaWendyl D'SouzaSamuel Frank BerkovicJohn-Paul NicoloTerence J O'BrienPiero PeruccaIngrid Eileen SchefferPatrick KwanPublished in: Epilepsia open (2023)
More than half of patients diagnosed with Lennox-Gastaut Syndrome (LGS) at three Australian epilepsy monitoring units between 1995 and 2015 did not meet the recently devised International League Against Epilepsy (ILAE) diagnostic criteria for LGS. Mortality was equally high in those who did and did not meet the ILAE diagnostic criteria, and seizure-related injury was common. The ILAE diagnostic criteria will guide accurate diagnosis, management, prognostication, and research in patients with LGS, however may be limited in their practical application to patients with a longer duration of epilepsy, or to those for whom detailed assessment is difficult.