Notch Signaling Suppression by Golden Phytochemicals: Potential for Cancer Therapy.
Masumeh Kaveh ZenjanabNastaran HashemzadehSajjad AlimohammadvandMasoumeh Sharifi-AzadElaheh Dalir AbdolahiniaRana Jahanban-EsfahlanPublished in: Advanced pharmaceutical bulletin (2024)
Cancer is one of the main causes of mortality worldwide. Cancer cells are characterized by unregulated cellular processes, including proliferation, progression, and angiogenesis. The occurrence of these processes is due to the dysregulation of various signaling pathways such as NF-κB (nuclear factor-κB), Wnt/beta-catenin, Notch signaling and MAPK (mitogen-activated protein kinases). Notch signaling pathways cause the progression of various types of malignant tumors. Among the phytochemicals for cancer therapy, several have attracted great interest, including curcumin, genistein, quercetin, silibinin, resveratrol, cucurbitacin and glycyrrhizin. Given the great cellular and molecular heterogeneity within tumors and the high toxicity and side effects of synthetic chemotherapeutics, natural products with pleiotropic effects that simultaneously target numerous signaling pathways appear to be ideal substitutes for cancer therapy. With this in mind, we take a look at the current status, impact and potential of known compounds as golden phytochemicals on key signaling pathways in tumors, focusing on the Notch pathway. This review may be useful for discovering new molecular targets for safe and efficient cancer therapy with natural chemotherapeutics.
Keyphrases
- cancer therapy
- signaling pathway
- pi k akt
- drug delivery
- nuclear factor
- epithelial mesenchymal transition
- cell proliferation
- induced apoptosis
- toll like receptor
- current status
- stem cells
- oxidative stress
- papillary thyroid
- risk assessment
- type diabetes
- endothelial cells
- cardiovascular events
- single cell
- single molecule
- vascular endothelial growth factor
- young adults
- squamous cell carcinoma
- cardiovascular disease
- immune response
- risk factors
- coronary artery disease
- inflammatory response