Immunostimulatory effects of Toll-like receptor ligands as adjuvants in establishing a novel mouse model for pemphigus vulgaris.
Changxing GaoMei LiuYue XinYong ZengHui YangXinyu FanCheng ZhaoBo ZhangLingzhi ZhangJing J LiMing ZhaoZijun WangJunpeng ZhaoPublished in: Clinical and translational medicine (2024)
Immunization with desmoglein 3 and Toll-like receptor (TLR) ligands effectively induces pemphigus symptoms in wild-type mice, whereas complete Freund's adjuvant (CFA) fails. TLR ligands heightened the autoreactivity of donor cells in the adoptive transfer pemphigus model. CFA promoted regulatory T cells and IL-10-producing neutrophils, whereas TLR ligands downregulated CCL17 and IL-10, leading to more effective immune responses.
Keyphrases
- toll like receptor
- immune response
- regulatory t cells
- wild type
- inflammatory response
- nuclear factor
- mouse model
- dendritic cells
- induced apoptosis
- early stage
- type diabetes
- stem cells
- adipose tissue
- cell proliferation
- depressive symptoms
- skeletal muscle
- liver fibrosis
- metabolic syndrome
- cell death
- endoplasmic reticulum stress
- drug induced
- pi k akt