Comparative Outcomes of Levetiracetam and Phenobarbital Usage in the Treatment of Neonatal Seizures: A Retrospective Analysis.
Handan Hakyemez ToptanNazmiye Nilgun KaradagSevilay TopcuoğluElif OzalkayaEmre DincerHakan CakirAsli Okbay GunesGuner KaratekinPublished in: Healthcare (Basel, Switzerland) (2024)
This study underscores LEV's superior safety profile over PB in neonatal seizure management, evidenced by a significantly lower rate of adverse events. PB seems to be more effective in the second-line treatment of neonatal seizures. Despite the lack of significant differences in the discharge rates, the higher mortality rate associated with LEV warrants further investigation. These findings advocate the cautious selection of antiepileptic drugs in neonatal care, with a preference for LEV based on its safety profile.