Intermitochondrial cement (IMC) harbors piRNA biogenesis machinery and exonuclease domain-containing proteins EXD1 and EXD2 in mouse spermatocytes.

Opeyemi OlotuMark DowlingDavid HomolkaMagdalena N WojtasPanyi TranTiina LehtiniemiMatteo Da RosRamesh S PillaiNoora Kotaja

Published in: Andrology (2023)

Altogether, this study highlights the central role of the IMC as a platform for piRNA biogenesis, and suggests that EXD1 and EXD2 function in the IMC-mediated RNA regulation in postnatal male germ cells.

Keyphrases

induced apoptosis
cell cycle arrest
preterm infants
high throughput
oxidative stress
cell death
signaling pathway
endoplasmic reticulum stress
cell proliferation