Urine Proteomics and Renal Single Cell Transcriptomics Implicate IL-16 in Lupus Nephritis.

Andrea Fava Deepak A RaoChandra MohanTing ZhangAvi RosenbergParide FenaroliH Michael BelmontPeter M IzmirlyRobert ClancyJose Monroy TrujilloDerek FineArnon AraziCeline C BerthierAnne DavidsonJudith A JamesBetty DiamondNir HacohenDavid WofsySoumya RaychaudhuriWilliam Apruzzesenull nullJill BuyonMichelle A Petri

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

Urine proteomics may profoundly change the diagnosis and management of lupus nephritis by noninvasively monitor active intrarenal biological pathways. These findings implicate IL-16 in lupus nephritis pathogenesis designating it as a potentially treatable target and biomarker.

Keyphrases

single cell
mass spectrometry
rna seq
label free
high throughput