Maternally inherited diabetes and deafness complicated by mesangial galactose-deficient IgA1 deposits: a case report.

Keiji SugaiHiroyuki UedaKeita MorimotoMai TanakaDaisuke TakahashiAkio NakashimaJunichiro KatoHiroshi TakahashiYutaka YamaguchiTetsuya KawamuraKazushige HanaokaYoichi MiyazakiTakashi Yokoo

Published in: BMC nephrology (2018)

We rediscovered the usefulness of GSECs as a pathologically distinctive feature of mitochondrial nephropathy and reviewed the literature regarding MIDD complicated by mesangial IgA deposition. Furthermore, we demonstrate that the mesangial IgA deposits in this patient consisted of the galactose-deficient IgA1 variant. The monoclonal antibody (KM55) might be a useful tool to distinguish IgAN from latent IgA deposits.

Keyphrases

monoclonal antibody
diabetic nephropathy
high glucose
type diabetes
systematic review
cardiovascular disease
oxidative stress
machine learning
glycemic control
skeletal muscle
adipose tissue