Lysosome targeted visible light-induced photo-CORM for simultaneous CO-release and singlet oxygen generation.

Upendar Reddy GandraBatakrishna JanaPatrick HammerM Infas H MohideenUte NeugebauerAlexander Schiller

Published in: Chemical communications (Cambridge, England) (2024)

We report a specific lysosome targeted light-responsive CO-releasing molecule (Lyso-CORM). Lyso-CORM is very stable under dark conditions. CO and singlet oxygen ( 1 O 2 ) generation was effectively triggered under one photon and two photon excitation (800 nm) conditions. The cytotoxicity results demonstrated that Lyso-CORM showed good phototoxicity due to the synergistic effect of CO and 1 O 2 release, and its good biocompatibility, negligible dark toxicity and specific lysosome targeting make Lyso-CORM a potent candidate for phototherapeutic applications.

Keyphrases

cancer therapy
living cells
fluorescent probe
drug delivery
energy transfer
oxidative stress
single molecule
electron transfer