Bifunctional photoelectrochemical aptasensor based on heterostructured Ag 3 PO 4 /Ag/TiO 2 nanorod array for determination of two tumor markers.
Pei SongMin-Li WangYi-Xin DuanAi-Jun WangYadong XueLi-Ping MeiJiu-Ju FengPublished in: Mikrochimica acta (2023)
Constructing of heterostructures can significantly improve the photoelectrical (PEC) response signal by promoting the migration and suppressing the recombination of photogenerated carries. A bifunctional PEC sensing platform was designed for simultaneous high-performance detection of mucin-1 (MUC1) and carcinoembryonic antigen (CEA), which was based on generated Z-scheme heterostructured Ag 3 PO 4 /Ag/TiO 2 nanorod arrays (NAs) and enzyme-mediated catalytic precipitation by alkaline phosphatase (ALP) and Au/hollow Co 3 O 4 polyhedron. The proposed aptasensor displayed linear ranges of 1.0-100 ng mL -1 and 0.1-50 ng mL -1 for MUC1 and CEA with limit of detections of 0.430 and 0.058 ng mL -1 , respectively. This strategy offers potential applications for early diagnosis, monitoring progression, and even evaluating the prognosis of breast cancer in practice.
Keyphrases
- visible light
- quantum dots
- sensitive detection
- label free
- highly efficient
- primary care
- high throughput
- healthcare
- molecularly imprinted
- metal organic framework
- loop mediated isothermal amplification
- dna damage
- high resolution
- dna repair
- signaling pathway
- high density
- risk assessment
- climate change
- solid phase extraction
- young adults
- tandem mass spectrometry
- breast cancer risk