Macrocyclic MR contrast agents: evaluation of multiple-organ gadolinium retention in healthy rats.

Simona BussiAlessandra CoppoRoberto CelesteAntonello FanizziAlberto Fringuello MingoAndrea FerrarisCatherine BotteronMiles A KirchinFabio TedoldiFederico Maisano

Published in: Insights into imaging (2020)

Less Gd is retained in the brain and body tissues of rats 28 days after the last exposure to ProHance® compared to other macrocyclic GBCAs, likely due to unique physico-chemical features that facilitate more rapid and efficient clearance.

Keyphrases

contrast enhanced
magnetic resonance
gene expression
white matter
resting state
computed tomography
functional connectivity