Class I histone deacetylase inhibitor MS-275 attenuates vasoconstriction and inflammation in angiotensin II-induced hypertension.
Yuhee RyuHae Jin KeeSimei SunYoung Mi SeokSin Young ChoiGwi Ran KimSeung-Jung KeeMarc PfliegerThomas KurzHyung-Seok KimMyung Ho JeongPublished in: PloS one (2019)
Our results indicate that class I HDAC selective inhibitors may be good therapeutic agents for the treatment of hypertension through the regulation of vascular remodeling and vasoconstriction, as well as inflammation.