Metabo-Endotypes of Asthma Reveal Differences in Lung Function: Discovery and Validation in two TOPMed Cohorts.

Rachel S KellyKevin M MendezMengna HuangBrian D HobbsClary B ClishRobert GersztenMichael H ChoCraig E Wheelock Michael J McGeachie Su H Chu Juan C CeledónScott T WeissJessica Lasky-Sunull null

Published in: American journal of respiratory and critical care medicine (2021)

Clinically meaningful endotypes may be derived and validated using metabolomic data. Interrogating the drivers of these metabo-endotypes has the potential to help understand their pathophysiology.

Keyphrases

lung function
chronic obstructive pulmonary disease
cystic fibrosis
air pollution
small molecule
electronic health record
genome wide
high throughput
big data
dna methylation
human health
gene expression
artificial intelligence