Neuron-specific deletion of presenilin enhancer2 causes progressive astrogliosis and age-related neurodegeneration in the cortex independent of the Notch signaling.

Hui-Ru BiCui-Hua ZhouYi-Zhi ZhangXu-Dong CaiMu-Huo JiJian-Jun YangGui-Quan ChenYi-Min Hu

Published in: CNS neuroscience & therapeutics (2020)

Pen-2 is required for neuronal survival in the adult cerebral cortex. The Notch signaling may not be involved in neurodegeneration caused by loss of Pen-2.

Keyphrases

functional connectivity
cerebral ischemia
multiple sclerosis
subarachnoid hemorrhage
transcription factor
brain injury
young adults